The detection of Omicron-associated mutations in community wastewater provides strong early evidence that the Omicron variant was likely present or more widely distributed in these communities than originally indicated by clinical testing alone Omicron-associated mutations were documented during November 2021, at least a week before the first U.S.
Reporting times >1 week can limit the usefulness of this data. Limitations of variant tracking in wastewater include detections inconsistent with the current epidemiology, low quality sequence data, sporadic detections, detection of a single variant-associated mutation, and conflicting trends in concentration or abundance data for mutations associated with the same variant. However, conditions that increase confidence in the results include detection of multiple variant-associated mutations linked mutations (i.e., on the same sequence read), or unique mutations not shared by other known variants RNA concentration data consistent with emergence (e.g., low initial concentrations, increasing over time) the reporting of clinical cases in the area detections in consecutive samples or via multiple methods and RNA concentration or sequence abundance data for multiple variant-associated mutations trending together. Variant tracking data from wastewater cannot confirm the presence of a specific variant because the methods used cannot determine whether all variant-defining mutations are present on a single genome. The wastewater surveillance programs in these four states were the first to detect evidence of Omicron in community wastewater. This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy. This report describes the initial detections in wastewater during November 21–December 16, 2021, and the interpretative framework for these types of data. Health departments in four states (California, Colorado, New York, and Texas) were the first wastewater surveillance programs to detect evidence of Omicron in community wastewater. In addition to total SARS-CoV-2 testing, some health departments track SARS-CoV-2 variants by detecting variant-associated mutations in wastewater. The National Wastewater Surveillance System (NWSS) comprises 43 health departments funded by CDC to provide data on presence of and trends in SARS-CoV-2 infections that are independent of clinical testing. COVID-19 cases.* Early warning systems, such as sewage (wastewater) surveillance, † can help track the spread of SARS-CoV-2 variants across communities ( 2). By December 18, Omicron was estimated to account for 37.9% of U.S. Omicron COVID-19 case was reported on December 1 ( 1). View all the available A5 Traveler's Notebook colors.The United States designated the B.1.1.529 (Omicron) variant of SARS-CoV-2 (the virus that causes COVID-19) a variant of concern on November 30, 2021, and the first U.S. What fits: Two Leuchtturm1917 notebooks, Two Rhodia Web Notebook A5, Four Rhodia Heritage A5 size, Four Moleskine Cahier large size, Two Nanami Sevenseas Notebook, Two Baron Fig Notebooks, Two Hobonichi Cousin Planner, Leuchtturm1917 Daily monthly planner + Any A5 notebook.Īny insert at size 8.27" x 5.83" or 2 Leuchtturm1917 A5 Classic Notebook or leather journals. The size makes them easy to carry while still allowing lots of space. A5 Traveler's Notebook Traveler's Notebook A5:Īt half the size of the A4, the A5 size notebooks are very popular as journals, planners or diaries.
Below you will find more in-depth descriptions and the exact dimensions for each size. Our latest post on the notebook sizes for these fits in perfectly with this post to help you decide which size to buy. We also have a variety of refill notebooks for your traveler's notebook. You can see the above image to get an idea of the various sizes of travelers notebook covers we offer. We frequently receive a lot of questions about our Traveler's Notebook cover sizes.